1. Iran's nuclear ambitions.
2. The Sunni nations' current anger with Obama.
3. The internecine bloodbath in Syria.
4. The Sunni-Shi'ite schism.
5. The fragmentation of Iraq.
6. Continuing turmoil in Egypt.
7. Libya's slide into anarchy.
8. The proliferation of Al-Quaeda terrorist groups.
9. Middle Eastern misogyny.
10. The persecution of Christians in the Islamic world.
And several other curses of the region.
Just go here (a not unimportant article) to see if you guessed right.